Our results show that 34-week-old APP/PS1 mice have increased deposition of senile plaques in the hippocampus and cortex, as well as increased Iba1 + microglia around senile plaques, suggesting the impaired ability of Iba1 + microglia to phagocytose Aβ, and increased levels of neuroinflammatory cytokines TNF-α, IL-6, and IL-1β in the hippocampus and cortex. Here, TNF is linked to Senile plaques.