In silico analysis of transcription factors responsible for differential gene expression of BCR-ABL-independent TKI-resistant CML cells revealed that AP-1 and NF-κB were the most enriched transcription factors among regulators of differentially expressed genes compared with randomly selected genes (Fig. 1D-F and Additional file 1: Fig. S3). This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.