TP53 and cancer: Moreover, several recent studies illustrated the prognostic importance of somatic mutations in critical cancer genes, such as mixed-lineage leukemia-partial tandem duplication, internal tandem duplication in Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD), tumor protein p53 (TP53) and ASXL transcriptional regulator 1 (ASXL1) mutations, and isocitrate dehydrogenase 1 (IDH1) mutations [7].