HEY1 and colorectal cancer: This includes endothelial differentiation with 2 genes, involved in lymphatic and arterial endothelial cell differentiation, downregulated 2 × (pathway 1), 2 pathways involved in colorectal cancer (pathway 2 and 3), γ-secretase regulation of angiogenesis with Hey-1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1), a promotor of endothelial cell proliferation, downregulated 3x (pathway 4), and IL-2 mediated enhancement of NK cell cytotoxicity with 3 pathway components downregulated 2-3x (pathway 5) (Fig. 4D).