Subsequently, cluster analysis, topological parameters analysis and functional enrichment analysis helped in identifying 4 genes viz., AGT (Gene ID: 183), LPL (Gene ID: 4023), ITGB2 (Gene ID: 3689), and IRS1(Gene ID: 3667) from cluster 3 that may be considered to be most influential in the pathogenesis of atherosclerosis. This evidence concerns the gene IRS1 and atherosclerosis.