Since CD4+ Th2 cells and Th2 cytokines such as interleukin-4 (IL-4), IL-5, IL-6, IL10 and IL13 were thought to be associated with immunosuppressive contexture and tumor-promoting effects [38–43], we believed that LMNB1 could be considered as a biomarker of immunosuppressive microenvironment. This evidence concerns the gene IL4 and neoplasm.