To the best of our knowledge, this is the first pan-cancer analysis of LMNB1 gene, which showed that LMNB1 is not only a biomarker of CD4+ Th2 cell infiltration and DNA homologous recombination repair, but also a promising therapeutic target to redress Th1/Th2 imbalance and enhance PARPi response. This evidence concerns the gene LMNB1 and cancer.