In order to investigate the effects of LMNB1 on the PARPi therapy, we stably knocked know LMNB1 in another PRAD cell line 22Rv1, by infecting with two lentiviruses containing specific short hairpin RNAs (shRNAs) targeting different regions of LMNB1 gene (Fig. 7A, Additional file 2: Table S2). This evidence concerns the gene LMNB1 and prostate adenocarcinoma.