Considering that malignant tumors often show a unique immunosuppressive microenvironment mediated by varieties of inflammation-related stromal cells and tumor-infiltrating immune cells, which results in poor response to immunotherapy and worse prognosis [20–23], and previous research indicated a significant correlation between LMNB1 expression and several kinds of tumor infiltrating lymphocytes in renal cell carcinoma [24], so we further investigated whether LMNB1 is involved in immune signaling pathways in a systematic pan-cancer manner, aiming to identify novel therapeutic strategy. This evidence concerns the gene LMNB1 and neoplasm.