Consistently, in the LMNB1-related cellular process in cancer cells including “nuclear division”, “organelle fission”, “mitotic nuclear division” and “chromosome segregation”, which were enriched by GO pathway analysis using TCGA data, we found several HRR genes such as BRCA1, CHEK1, RAD51, RAD54L and BRIP1 were implicated. The gene discussed is CHEK1; the disease is cancer.