LMNB1 and prostate adenocarcinoma: Finally, GSEA of PRAD cohort in TCGA database showed that the pathways of “DNA repair” in hallmark gene set (Fig. 7D, E, Additional file 3: Table S3), “homologous recombination”, “mismatch repair”, “nucleotide excision repair”, “base excision repair” in KEGG gene set (Additional file 1: Fig. S5A, B, Additional file 4: Table S4), and “double strand break repair” in GO biological process gene set (Additional file 1: Fig. S5C, D, Additional file 5: Table S5) were positively associated with high LMNB1 expression, indicating that LMNB1 did play a crucial role on DNA repair and PARPi therapy.