Firstly, Sangerbox tools helped us identified that activated CD4+ T cells and type 2 T helper cells were the main immune pathways which were significantly correlated with high expression of LMNB1 in most of human cancer types, especially ACC, KIRP, KIRC, LIHC, LGG, PRAD, THCA and UVM (Fig. 4A). Here, CD4 is linked to cancer.