Although recent accumulating evidence suggests that early surgical intervention may not always be required for acute appendicitis because of the relatively high success rate of antibiotic therapy [4–10], some studies have suggested that nonoperative management with antibiotics is not always effective in patients with acute appendicitis with a high serum CRP level, presence of an appendicolith, large appendiceal diameter, or complicated acute appendicitis [25–27]. The gene discussed is CRP; the disease is appendicitis.