TNF and COVID-19: Based on the above details, we find that A. annua can play a therapeutic role in the entire process of COVID-19 management thus, meeting the need for the systematic treatment of COVID-19 and futuristic studies, it would be worthwhile to explore the role of VEGFA, CASP3, TP53, TNF, MAPK1, MAPK8 and MAPK14 in the mechanisms manifested by A. annua.