Based on the above details, we find that A. annua can play a therapeutic role in the entire process of COVID-19 management thus, meeting the need for the systematic treatment of COVID-19 and futuristic studies, it would be worthwhile to explore the role of VEGFA, CASP3, TP53, TNF, MAPK1, MAPK8 and MAPK14 in the mechanisms manifested by A. annua. The gene discussed is TP53; the disease is COVID-19.