Long ncRNA CCAT1 induced chemoresistance of ESCC cells to DDP by targeting the miR-143/PLK1/BUBR1 axis [18], and lncRNA LINC00337 promoted DDP resistance in ESCC cells through upregulating TPX2 by recruiting E2F4 [26]. This evidence concerns the gene E2F4 and esophageal squamous cell carcinoma.