The modification effect of ALKBH3 on m1A methylation is opposite to that of TRMT6 and TRMT61A, however, as revealed by the above studies and our results, a poor prognosis was consistently observed in HCC patients with an elevated TRMT6/ TRMT61A or ALKBH3 expression level, suggesting the crucial role of m1A methylation dysfunction in HCC. This evidence concerns the gene TRMT6 and hepatocellular carcinoma.