TP53 and hepatocellular carcinoma: TP53 mutation, which has been demonstrated as an important tumorigenesis procedure [36] and to enhance aerobic glycolysis of tumor cells [37], was found to positively correlate with the genetic changes of m1A regulators in HCC, and mutation frequency of TP53 in low- and high-m1Ascore groups were also found significantly different in our study (22% vs. 37%, P = 0.003).