A recent study reported that the expression levels of writers TRMT6 and TRMT61A in HCC tissues were significantly increased and showed that the increased TRMT6 and TRMT61A expression levels are negatively associated with patients’ prognosis, and found that TRMT6/TRMT61A-mediated m1A methylation can initiate liver tumorigenesis by regulating lipid metabolism [27]. This evidence concerns the gene TRMT61A and hepatocellular carcinoma.