In sepsis, molecular hydrogen therapy effectively improved mitochondrial function, reflected by the blocking of mitochondrial permeability transition pore openings, and an increase in mitochondrial-membrane potential and adenosine triphosphate (ATP) levels, respiration control ratio, mitochondrial–respiration complex activities, and Mfn2 expression along with a decrease in the histological score and dynamin-related protein 1 levels (Dong et al. 2018). The gene discussed is MFN2; the disease is Sepsis.