HMOX1 and Sepsis: In myocardial tissues with severe sepsis, molecular hydrogen gas treatment led to upregulated HO-1 and the expression of mitofusin-2 (Mfn2) and peroxisome proliferator-activated receptor-gamma coactivator-1α, while limiting severe sepsis-related mitochondrial dysfunction (Zhang et al. 2020) and restoring cardiac fatty acid oxidation by increasing cardiac energy in sepsis (Tao et al. 2015).