CD226 and COVID-19: In patients with COVID-19, the level of von Willebrand factor, which is a circulating adhesive glycoprotein secreted by ECs, is considerably elevated (Panigada et al. 2020), directing both endothelial infection with SARS-CoV-2 and the indirect damage caused by inflammation in COVID-19-associated coagulopathy (Iba et al. 2020).