NLRP3 and acute respiratory distress syndrome: At present, the inhibition of the NLRP3 inflammasome is an attractive and effective treatment for ALI caused by various pathogenetic factors such as LPS-induced ALI, ventilator-induced lung injury (VILI), and hyperoxia-induced ALI (HILI) (Kuipers et al. 2012; Hong et al. 2019; Wang et al. 2019b).