Leveraging an LPA-derived phenotype and genetics data, we identified two genome-wide significant loci in our genome-wide association analysis for LPAx (a data-derived cognitive impairment outcome): TEAD4 (rs11829294, p value = 2.40e-8) and STX18 (rs79453226, p value = 1.91e-8). The gene discussed is TEAD4; the disease is Cognitive impairment.