The PPI of PMIBcr/Abl‐R6 treatment‐induced protein variation showed that SHC1, NUP214, NPM1, CAV1, CD38, MME, DNTT, PARP1, GNAS, NRP1, DOK3, and STAT1 interacted directly with Bcr/Abl, indicating that these proteins may be important for the PMIBcr/Abl‐R6 mechanism in p190 ALL. Here, SHC1 is linked to acute lymphoblastic leukemia.