Therefore, this study aimed at: 1) assessing whether T2DM affects microvascularfunction equally in postmenopausal women and men at a similar age compared withtheir nondiabetic counterparts; and 2) investigating circulatory biomarkers directlyrelated to: a) T2DM (glycemia, HbA1c, Nε-carboxymethyllysine (CML), and advancedglycation end products (AGEs)); b) CVD (nitrate/nitrite, C-reactive protein (CRP),and lipid profile); and c) pro- and anti-inflammatory adipokines, tumor necrosisfactor-alpha (TNF-alpha), and adiponectin. This evidence concerns the gene TNF and type 2 diabetes mellitus.