The main finding of this study was that postmenopausal women with T2DM withoutprevious CVD events had impaired microvascular function that was accompanied by ahigh plasma concentration of two pro-inflammatory mediators, CML and CRP, and alower level of anti-inflammatory adipokine, adiponectin, even though glycemia wassignificantly lower compared to diabetic men at a similar age. This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.