The presence of T2DMsignificantly affected the concentration of adiponectin in postmenopausal women,about 32% of reduction (control: 13.8±1.8 and T2DM women: 9.3±1.2 ug/mL,P<0.05), whereas this anti-inflammatory adipokine was not altered in men(control men: 6.2±0.6 vs T2DM men: 5.4±0.7 ug/mL, P>0.05).As expected, a sex difference was observed in adiponectin level both innondiabetic and diabetic groups (Figure2A). The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.