The probable explanations were as follows: 1) Regarding cognition impairment, TNF-α served as a common inflammation cytokine, and the possible reason for its correlation with cognition impairment was as mentioned above; high NIHSS score meant worse neurological status in AIS patients, and cognition impairment was also a kind of manifestation of neurological dysfunction, hence, an NIHSS score ≥5 was an independent risk factor for cognition impairment. The gene discussed is TNF; the disease is Cognitive impairment.