Extensive studies in recent years have led to the description of key genetic changes in the late-onset of FECD, which include genes for transcription factor 4 [6], transcription factor 8 [7], ATP/GTP-binding protein-like 1 [8], and solute carrier family 4 member 11 [9]. The gene discussed is ZEB1; the disease is Fuchs endothelial corneal dystrophy.