It has been proposed that clozapine can induce c-Fos expression in the forebrain regions related to the action of antipsychotics such as NaC, LS and mPFC, but not in the dorsal striatum [27, 29, 34], reducing positive and negative symptoms of schizophrenia with low extra-pyramidal side effect [28, 29, 35]. This evidence concerns the gene FOS and schizophrenia.