Using genetic instruments and under the assumptions of Mendelian randomization, our findings are consistent with higher levels of GCNT4, RAB14, C1GALT1C1, CD207 and ABO causally increasing the risk of both hospitalization and need of respiratory support or death due to COVID-19, and higher levels of FAAH2 increasing the risk of hospitalization. Here, GCNT4 is linked to COVID-19.