CTLA4 and neoplasm: However, LEM significantly reduced PD-L1 expression on tumor cells (Figure 5A), and tumor-infiltrating monocytic MDSCs (M-MDSCs) (Figure 5B), PMN-MDSCs (Figure 5C), and CD11b+CD11c+ double-positive cells (Figure 5D), with or without anti–CTLA-4 therapy.