Reintroduction of CCT4 or mLST8 expression in YB-1–knockdown GSCWL1 and GSC456 cells reactivated mTOR signaling (Figure 6, A and B) and partially rescued cell proliferation, tumor-sphere formation, and GSC self-renewal (Figure 6, C–H). The gene discussed is MLST8; the disease is neoplasm.