Introduction of CCT4 or mLST8 into YB-1–knockdown cells partially rescued in vivo tumor cell growth (Figure 7, A–C, and Supplemental Figure 6, A–C) and the intratumoral activity of both mTOR1 and mTOR2 signaling (Figure 7D and Supplemental Figure 6D). The gene discussed is CCT4; the disease is neoplasm.