Although we did not observe a significant change in YB-1 expression after the treatment with mTOR inhibitors in glioblastoma cells (data not shown), these data suggest that besides YB-1 autoregulation, YB-1/CCT4/mLST8/mTOR might form a positive feedback loop leading to altered proteostasis networks in certain tissues. The gene discussed is CCT4; the disease is glioblastoma.