Interestingly, total IgA-coated organisms isolated from IBD patient feces include at least a subset of organisms that efficiently colonize the colonic mucus layer and increase susceptibility of colonized mice to experimental colitis.2 The IgA-coated bacteria, which represent a minority of the total luminal community, are coated by both IgA1 and IgA286 suggesting potential cooperation between T-dependent and T-independent responses in luminal sequestration. This evidence concerns the gene CD79A and colitis.