2007). Increased activity of endothelial NOS (eNOS) and expression of inducible NOS (iNOS) were observed in exercised animals. While exercise effectively attenuated infarct size following myocardial IR in wild‐type mice, eNOS–/– and iNOS–/‐ variants were resistant to the exercise‐induced cardioprotection (Akita et al. 2007). In humans, 3 days of interval exercise may largely improve NO‐mediated, flow‐mediated dilatation in patients with rest angina (Morikawa et al. 2013), suggesting a potential role for NOS systems (and its relation to endothelial function) in SEP. Here, NOS2 is linked to intermediate coronary syndrome.