We investigated the role of P2RX7 in three rat models of GN: (1) NTN, a passive model of crescentic GN induced by immunisation with heterologous rabbit antirat glomerular basement membrane (GBM) serum [32]; (2) EAG, an autoimmune model of anti‐GBM disease induced by immunisation with recombinant rat α3(IV)NC1, the Goodpasture autoantigen [42]; and (3) EAV, an autoimmune model of antimyeloperoxidase (MPO) vasculitis induced by immunisation with human MPO [43]. This evidence concerns the gene MPO and ganglioneuroma.