Taken together, these findings, in three experimental models of GN in WKY WT and P2RX7 KO rats, convincingly indicate that P2RX7 is not critical in mediating GN or autoimmunity in the rat and that unlike AZ11657312, A‐438079 at the dose used is mediating its effects via off‐target mechanisms. Here, P2RX7 is linked to ganglioneuroma.