Our previous study, which used NCD‐fed rats, showed that food restriction by pair‐feeding to E2 replacement group in the PL group ameliorated hyperglycemia in the OVX rats but failed to mimic the effects of E2 replacement on basal levels of insulin signaling components, Akt2 and AS160 (Kawakami et al., 2019). Here, TBC1D4 is linked to Hyperglycemia.