Furthermore, one NTRK1-rearranged case with distant metastases (case 52) had synchronous sigma tumour with proficient (p)MMR and KRASG12V mutation, as was also shown to be the case for the peritoneal metastasis, whilst the NTRK1-rearranged tumour in colon ascendens was dMMR and RASwt. This evidence concerns the gene MRC1 and neoplasm.