The EML4(e21)::ALK(e20) fusion with non-canonical breakpoint of EML4 gene at exon 21 has been reported to constitute only about 2% of the ALK-rearrangements in non-small cell lung cancer, where EML4(e6)::ALK(e20) is the most common EML4::ALK variant [31]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.