Seven in-frame NTRK1 fusions (Table 2) were identified (TPM3::NTRK1, PLEKHA6::NTRK1 and LMNA::NTRK1, each in two cases, and IRF2BP2::NTRK1 in one case), of which IRF2BP2::NTRK1 is a novel fusion in CRC (Fig. 1). The gene discussed is PLEKHA6; the disease is colorectal carcinoma.