ASCT2 suppression significantly decreased glutamine uptake, which led to a decrease in the phosphorylation of Akt kinase on Ser473, the 70-kDa ribosomal protein S6 kinase and eukaryotic initiation factor-4E (eIF4E) binding protein-1 (4E-BP1) in prostate cancer [13], breast cancer [28] and hepatocellular carcinoma [27]. This evidence concerns the gene EIF4E and hepatocellular carcinoma.