ADCYAP1 and Parkinson disease: Native PACAP has been demonstrated to be neuroprotective in diverse animal models of neurodegenerative disorders and neurological insults including Alzheimer’s disease (Onoue et al., 2002; Kojro, 2006; Rat et al., 2011), Parkinson’s disease (Reglodi et al., 2004a; Reglodi et al., 2004b), cerebral ischemia (Chen et al., 2006; Dejda et al., 2011), TBI (Farkas et al., 2004; Kóvesdi et al., 2008; Bukovics et al., 2014), and alcohol toxicity (Vaudry et al., 2002; Vaudry et al., 2005; Botia et al., 2011).