Moreover, several blood components can cross the leaky endothelium of a tumor, among them albumin-bound FA, and very low density lipoprotein (VLDL) and LDL particles, which can release FA by the local actions of lipoprotein lipase and secreted phospholipase A2, thereby enhancing the FA pool of the tumor microenvironment (132). This evidence concerns the gene LPL and neoplasm.