The validated function of the Wnt ligands (WNT 2, 3, 3a, 4, 5a, 5b, 6, 7a, 7b, 9a, 10a, 10b, and 11) and their receptors (FZD1, 2, 6, and 7) in BC were recently reviewed in some detail by Xu and his colleagues (Xu et al., 2020). This evidence concerns the gene FZD1 and breast cancer.