Remarkably, FZD6 has been reasonably studied in other cancer types such as oral (Putnová et al., 2021), prostate (Vatansever et al., 2014), thyroid (Deng et al., 2015), pancreatic adenocarcinoma (Li et al., 2021), osteosarcoma (De Sá Rodrigues et al., 2017), and leukemia (Wu et al., 2009). Here, FZD6 is linked to osteosarcoma.