The systematic review and evidence GRADE process previously conducted (5), indicated strong evidence for TG responsiveness to EPA and/or DHA based on APOE (rs429358, rs7412) genetic variants in men (GRADE evidence quality rating: moderate) (16–24), and TG responsiveness to EPA+DHA based on a 31-SNP nutri-GRS in men and women with overweight/obesity (GRADE evidence quality rating: high) (25, 26). The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.