APOE and obesity due to melanocortin 4 receptor deficiency: • Given that the level of evidence is higher for the 31-SNP nutri-GRS compared to APOE rs429358 and rs7412, the nutri-GRS result should be used to guide practice related to TG management in lieu of the APOE result if results are conflicting among patients who fall within the generalizable population stated below. For example, EPA+DHA for TG reduction should be recommended to adult male patients with overweight/obesity who have a low nutri-GRS, even if they are not APOE E4 carriers. • Generalizable population: adult males with overweight/obesity