The median IHC scores of both lining and sublining IL-6 expression were significantly higher in RA patients than that in OA [Lining: 2.6 (1.2, 5.5) vs. 1.0 (0.9, 1.8), p = 0.049; Sublining: 2.2 (1.2, 2.6) vs. 0.7 (0.5, 1.0), p = 0.011], or Orth. The gene discussed is IL6; the disease is rheumatoid arthritis.