A study has implicated the importance of GSDMD-mediated monocytes pyroptosis in RA pathology (Wu et al., 2020), and Ze-Qing Zhai’s latest article revealed a pathogenic role of GSDME in the pyroptosis of monocytes and macrophages in RA (Zhai et al., 2021). This evidence concerns the gene GSDMD and rheumatoid arthritis.