Furthermore, weighted correlation network analysis (WGCNA) showed that GSDME was annotated against THY-1(+) fibroblast cell population (Supplementary Figure S1B), which was found to be remarkably expanded in RA synovium compared to control synovium and correlated with severe and persistent inflammation in RA (Croft et al., 2019; Wei et al., 2020). This evidence concerns the gene THY1 and rheumatoid arthritis.