RA patients with high GSDME-NT expression possess higher IL-6 IHC scores than those with low GSDME-NT expression [Lining: 2.8 (2.4, 5.6) vs. 1.1 (0.8, 3.4), p = 0.047; Sublining: 2.2 (1.4, 2.8) vs. 1.0 (0.8, 1.8), p = 0.029], suggesting that GSDME-mediated pyroptosis can obviously affect the synovial IL-6 level (Figure 5E). The gene discussed is IL6; the disease is rheumatoid arthritis.