GSDMD and Hyperglycemia: The basic process is that when multiple pathological factors such as oxidative stress, hyperglycemia and inflammation stimulate the organism, cells receive endogenous and exogenous danger signals to induce intracellular formation of inflammatory vesicles, activating caspase-1, that in return mediates the maturation and extracellular production of pro-inflammatory factors via gasdermin D (GSDMD) (Vande Walle and Lamkanfi, 2016; Barnett and Ting, 2020).