BECN1 and heart failure: Tat-Beclin 1, aforementioned autophagy enhancer liberating beclin 1 from Golgi complex, was shown to confer beneficial effects on heart failure after transverse aortic constriction (TAC) (Shirakabe et al., 2016), which is consistent with a previous report that cardiac autophagy plays a protective role in ischemic cardiac disease of mice with diet-induced obesity (Sciarretta et al., 2012).