GLP1R and fatty liver disease: While GLP-1 receptor agonists may upregulate autophagy in several tissues including the liver and thereby improve liver steatosis (Sharma et al., 2011; Noyan-Ashraf et al., 2013; Fang et al., 2020), the mechanism of autophagy induction by of GLP-1 receptor or other G-protein-coupled receptors (GPCR) is unclear (Wauson et al., 2014).