Mice with deletion of Atg7 in agouti-related protein (AgRP) neurons producing orexigenic hormones such as AgRP and neuropeptide Y (NPY) showed reduced fat mass and decreased hyperphagic response (Kaushik et al., 2011), while proopiomelanocortin (POMC) neuron-specific Atg7-KO mice showed obese phenotype and aggravated glucose intolerance after high-fat diet (HFD) feeding imposing metabolic stress (Coupe et al., 2012; Kaushik et al., 2012; Quan et al., 2012b) (Figure 1). The gene discussed is AGRP; the disease is Glucose intolerance.