In contrast, adipose-specific KO of autophagy genes such as Atg3, Atg16L1 or Beclin 1 during adult period led to mitochondrial dysfunction, hypertrophic adipocytes due to impaired lipolysis, adipocyte death or inflammation in adipose tissue and peripheral insulin resistance or impaired glucose intolerance (Cai et al., 2018; Son et al., 2020) (Figure 1). This evidence concerns the gene BECN1 and Glucose intolerance.