GPER1 and acute lymphoblastic leukemia: Our finding evidenced that the G-1 cytotoxicity against T-ALL cells is most likely triggered by mechanisms independent of the GPER, similar to some previous reports (Holm et al., 2012; Wang et al., 2012; Gui et al., 2015; Mori et al., 2015; Lv et al., 2017).