There are numerous studies that reported a specific GPER-dependent cytotoxic effect of G-1 in different cancer models (Albanito et al., 2007; Dennis et al., 2011; Imesch et al., 2013; Luo et al., 2014; Wei et al., 2014; Weißenborn et al., 2014; Cirillo et al., 2017; Ribeiro et al., 2017; Lee et al., 2019; Liu et al., 2019; Han et al., 2021; Zhou et al., 2021). Here, GPER1 is linked to cancer.