GPER1 and mantle cell lymphoma: G-1 is a highly selective GPER agonist, and many research groups have demonstrated that its cytotoxic and anti-proliferative effects are mediated by this receptor in the lungs (Liu et al., 2019), breast (Wei et al., 2014; Weißenborn et al., 2014), gastric (Lee et al., 2019), ovarian (Albanito et al., 2007; Han et al., 2021), and mantle cell lymphoma (Zhou et al., 2021) cell lines.