The GPER expression was revealed in most if not all normal tissues, and it has also been shown that the GPER plays an important role in the progression of various types of cancer, especially those dependent on hormones (Prossnitz and Barton., 2011; Jala et al., 2012; Girgert et al., 2019; Hsu et al., 2019; Jung, 2019; Xu et al., 2019). The gene discussed is GPER1; the disease is cancer.