Moreover, in diffuse large B-cell lymphoma (DLBCL), smoothened recruits Gαi and Gα12 and activates the protein kinase C (PKC)-caspase recruitment domain and membrane-associated guanylate kinase-like domain protein 1-dependent signaling cascade, which promotes activation of NF-κB, tumor growth, and anti-apoptosis (Qu et al., 2013). This evidence concerns the gene PRRT2 and diffuse large B-cell lymphoma.