p62 expression is age- and disease-dependent, characterized by a decline of expression with age and senescence in mice (Kwon et al., 2012; Salazar et al., 2020) and flies (Aparicio et al., 2019), as well as a decrease in human and mouse brains with Alzheimer’s disease (Du et al., 2009). This evidence concerns the gene SQSTM1 and Alzheimer disease.