For example, Andersen-Tawil Syndrome, a channelopathy associated with a mutation in the inwardly rectifying potassium channel Kir2.1, leads to multiple morphological and craniofacial defects including short stature, low-set ears, small-lower jaw, cleft palate, clinodactyly, and syndactyly (Tawil et al., 1994; Plaster et al., 2001; Perez-Riera et al., 2020). This evidence concerns the gene KCNJ2 and Cardiodysrhythmic potassium-sensitive periodic paralysis.