In our study, DDX31 might be a potential risk factor affecting poor survival status of pancreatic cancer patients by univariate (HR = 1.517; CI = 1.003–2.296) and multivariate (HR = 1.229; CI = 0.795–1.900) cox regression analysis, but not significantly statistical difference in multivariate cox regression analysis. This evidence concerns the gene DDX31 and familial pancreatic carcinoma.