In recent years, extensive research has been carried out on EMT-related signaling pathways and signal targets such as transforming growth factor (TGF)/SMADs, Ras/ERK1/2, Wnt/β-catenin, aiming to find the molecular mechanism of inhibiting or reversing EMT in tumor cells, so as to develop targeted drugs for controlling tumor invasion and metastasis (Sun et al., 2015). The gene discussed is MAPK3; the disease is neoplasm.