Part of these genes have been reported in basic studies of pancreatic cancer and are closely related to the invasion and metastasis of pancreatic cancer according to the literature, including MYC (Sodir et al., 2020), CDH2 (Shintani et al., 2008), SNAI1 (Dai et al., 2017), YAP1, SOX2 (Zhang et al., 2017). The gene discussed is CDH2; the disease is familial pancreatic carcinoma.