SORCS3 and Cognitive impairment: Previous study showed down-methylation of Irs1 in patients with cognition disorder; Sox5, as a transcription factor, is a critical modulator of neurite outgrowth (Naudet et al., 2018); Sorcs3 controls the proper positioning and mobility of glutamate receptors in the postsynaptic density, which is crucial to synaptic function and plasticity (Christiansen et al., 2017); and Specc1 has a strong link to cognitive abilities by remodeling small GTPases in the cytoskeleton (Maroteaux et al., 2012).