In family A (Figure 2A), the age of CeD diagnosis for the proband and two siblings are 18 years for III.2 and 12 years for III.4 and III.5, and the latter two showed elevated levels of tTG antibodies on an average level of 234.7 chemiluminescence unit (CU) when the normal range is <20. The gene discussed is TGM2; the disease is cranioectodermal dysplasia.