Results showed coffee consumption (OR=0.91, 95%CI: 0.83-0.99), microseminoprotein-beta (OR=0.96, 95%CI: 0.95-0.98), and pubertal development (OR=0.97, 95%CI: 0.94-1.00) may be causal protective factors of prostate cancer. Here, MSMB is linked to Familial prostate cancer.