Consistent with the findings in the previous meta-analysis, the conventional IVW method indicated a causal association between genetically predisposed IGFBP-3 and prostate cancer (OR=1.0002, 95%CI: 1.00004-1.0004, p=0.016), and weighted median methods also generated similar effect estimation (OR=1.0002, 95%CI: 1.0001-1.0004, p=0.0002). Here, IGFBP3 is linked to prostate cancer.