Interestingly, we observed upregulated expression of LINC00324 and downregulated expression of LOC100507053 linked with the age (>50 years) of the ESCC patients compared to age-matched healthy individuals (Table 1, Figures 2A and 3A), which suggests that the age above 50 years might affect the levels of LINC00324 and LOC100507053 expressions. This evidence concerns the gene LINC00324 and esophageal squamous cell carcinoma.