JAK2 p.L611S has been reported in the COSMIC database (COSV67633764, legacy identifier: COSM21361) for a total of 4 cases including PV (with comutation in JAK2 V617F), AML in conjunction with Down syndrome myeloid disorder (DS-AMKL) (comutated with GATA and NIPBL and 7qdel, B-ALL, and squamous cell carcinoma (COSM21361, February 2021). The gene discussed is JAK2; the disease is acute lymphoblastic leukemia.