Psmd2 regulates the expression of neo-lipid synthesis-related genes through p38-JNK and AKT signaling, thereby increasing the proliferation of HepG2 cells by promoting cellular lipid droplets, and highly expressed Psmd2 is significantly associated with poor prognosis in hepatocellular carcinoma [66]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.