PRKCE and cancer: In addition, we found that Prkce (named protein kinase C epsilon type), a calcium-independent, phospholipid- and diacylglycerol- (DAG-) dependent serine/threonine-protein kinase, also could play an essential role in the regulation of several cellular processes associated with cytoskeletal proteins and is involved in the regulation of immune response, cancer cell invasion, and apoptosis and was also shown lower expressed in rats with MCT-induced PAH [78].