Notably, the interaction results showed that 6 common upregulated genes (Psmd2, Psmc4, Psmc3, Psmc5, Psmd13, and Psmc2) and 3 common downregulated genes (Lipe, Cat, and Prkce) were included in two datasets (Figure 8), and these 9 genes significantly differentially expressed in GSE149713 as hub mitochondrial-related genes in PAH rats (Figure 9). The gene discussed is PSMC5; the disease is pulmonary arterial hypertension.