In this study, another important finding has shown that the hub mitochondrial-related proteins such as Psmd2, Psmc4, Psmc3, Psmc5, Psmd13, and Psmc2 are upregulated in PAH rat lung tissue, and there are 32 miRNAs targeted to these hub genes for regulating the occurrence of rats with PAH. This evidence concerns the gene PSMC4 and pulmonary arterial hypertension.