Based on data from all three phase III ORION studies, that is ORION-9, ORION-10, and ORION-11, which have confirmed the robust LDL-C lowering with inclisiran (284 mg) in the long-term with reduced plasma PCSK9 levels by approximately 80%, it seems that inclisiran is the first-in-class siRNA-based drug, which is not only efficient in changing the lipoprotein profile into a favorable one in patients with dyslipidemia, particularly in those with elevated LDL-C, but also has a very good safety profile [23, 29]. The gene discussed is PCSK9; the disease is metabolic syndrome.