AXIN2 and acute myeloid leukemia: Furthermore, iron load in colorectal cancer cells can promote the Wnt signaling and cell proliferation [40], but iron chelators, including deferoxamine, deferoxamine, and ciclopirox, can inactivate the Wnt signaling, and AML patients taking cyclohexanolamine show a significant decrease in the expression of the Wnt target gene AXIN2.