Moreover, this study highlights that the use of a custom capture-based target enrichment NGs panel -containing 16 genes to date known as being associated with Familial Chylomicronemia Syndrome and severe hypertriglyceridemia-allowed us to find a clear genetic pattern characterized by a rare variant in the apo-C3 gene together with four common SNPs that could be related to the onset of severe drug-induced Hypertriglyceridemia. Here, APOC3 is linked to hypertriglyceridemia.