Genomic DNA was extracted from peripheral blood and genetic screening was performed using a custom panel of 16 genes, associated to severe hypertriglyceridemia: APOA1, APOA4, APOA5, APOC1, APOC2, APOC3, APOC4, APOE, ANGPTL3, LPL, GPIHBP1, LMF1, GPD1, CREB3L3, GCKR, LRP1. Here, APOC3 is linked to hypertriglyceridemia.