CD8A and neoplasm: DAMPs can mediate the interaction between cancer cells and immune cells to trigger an anticancer-related immune response, such as the activation of cytotoxic CD8+ T lymphocytes, prompting DC to release proinflammatory cytokines and reduce Treg tumor immersion (Biswas and Mantovani, 2010; Werthmöller et al., 2015; Yatim et al., 2015; Sprooten et al., 2020).