CREBBP mutations have been associated with adverse outcome in FL (Pastore et al., 2015; Mondello et al., 2020) and DLBCL (Huang et al., 2021), however when discriminating point mutations from nonsense/frameshift mutations only failure-free survival remained significant, but not OS (Mondello et al., 2020). Here, CREBBP is linked to diffuse large B-cell lymphoma.