Comparing the mRNA expression levels of BIRC5, CAPS, CLDN7, CLVS1, GMIP, IFI16, and TCIRG1 in ccRCC patients and normal people, we found that BIRC5, CLVS1, GMIP, IFI16, and TCIRG1 were significantly overexpressed in ccRCC patients from TCGA-KIRC dataset and CAPS and CLDN7 had lower expression level in ccRCC patients than in normal people. This evidence concerns the gene CLDN7 and nonpapillary renal cell carcinoma.