A serious of analysis based on autophagy and DEGs was performed, and it turned out that a new risk score constructed by 7 ATGs (BIRC5, CAPS, CLDN7, CLVS1, GMIP, IFI16, and TCIRG1) could be a potential predictive signature of ccRCC patients. The gene discussed is IFI16; the disease is nonpapillary renal cell carcinoma.