We performed “Cibersort” on R studio to assess immune cell infiltration level in ccRCC patients and normal patients, macrophages M2, T cells CD8, macrophages M1, T cells gamma delta, T Cells regulatory, macrophages M0, NK cells resting, T cells CD4 activated and T cells follicular are significantly higher infiltrated in ccRCC patients than in normal patients (Figure 14A). This evidence concerns the gene CD4 and nonpapillary renal cell carcinoma.