As a result, to find out immune cells that had significant effects on ccRCC, we performed univariate and multivariate cox regression on immune cell infiltration and the results revealed that in TCGA-KIRC, mast cells resting suppressed tumor progression while macrophages M0, T cells CD4 memory activated, and T cells regulation were risk factors of tumor progression (Supplementary Material S3). The gene discussed is CD4; the disease is neoplasm.